Generation of leukotrienes from human granulocytes by alveolysin from Bacillus alvei.

نویسندگان

  • K D Bremm
  • H J Brom
  • J E Alouf
  • W König
  • B Spur
  • A Crea
  • W Peters
چکیده

We investigated the effect of alveolysin on human granulocytes. Alveolysin is an exoprotein produced by Bacillus alvei and belongs to the group of sulfhydryl-activated cytolysins. Other members of this group are streptolysin O and theta-toxin from Clostridium perfringens. It is demonstrated that alveolysin leads to leukotriene generation from human granulocytes, which exert chemotactic (leukotriene B4) and slow-reacting substance (leukotriene C4, D4, and E4) activity under sublytic concentrations.

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عنوان ژورنال:
  • Infection and immunity

دوره 44 1  شماره 

صفحات  -

تاریخ انتشار 1984